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The bioactivation of tramadol by CYP2D6 is a crucial supply of variability as a result of drug interaction. The analgesic efficacy of tramadol may be significantly minimized by CYP2D6 inhibitors, for instance some SSRIs or terbinafine [114, 115].If the reaction to opioid receptor antagonists is suboptimal or only quick in nature, yet another dose o